Di-2-ethylhexyl phthalate in bovine heart muscle mitochondria: its detection, characterization, and specific localization.

Some aspects of DEHP and its action on lipid metabolism.

In 1967, Nazir et al. (1,2) reported the specific localization of di-2-ethylhexyl phthalate (DEHP) in bovine heart muscle mitochondria. This led us to investigate the action of dietary DEHP in a number of selected tissues. Preliminary, unpublished studies have indicated that adipose tissue and total body weights were affected by the addition of DEHP to the diet. The purpose of this study was to...

Uptake and fate of Di-2-ethylhexyl phthalate in aquatic organisms and in a model ecosystem.

Di-2-ethylhexyl phthalate (DEHP), often referred to as dioctyl phthalate or DOP, is the most widely used plasticizer for vinyl plastics, and approximately 350 million pounds were produced in the United States during 1970. Altogether the production of phthalate ester plasticizers was 855 million pounds (1). The cumulative production of DEHP and related phthalate plasticizers in the United States...

Quantitative determination and confirmation of identity of trace amounts of dialkyl phthalates in environmental samples.

use as plasticizers for various types of synthetic resins and plastics is by far their most important industrial use. Recently they have been receiving publicity as possible environmental contaminants, since such plasticizers can volatilize on incineration or be leached from plastics present in landfill projects. Evidence of their presence in soil organic matter (1,2) in water (3), and in fish ...

Mitochondrial toxicity of phthalate esters.

The effects of mono- and dibutyl phthalate and mono- and di(2-ethylhexyl) phthalate on energy-dependent K+ uptake, respiration rates, and succinate cytochrome c reductase activities of isolated rat liver mitochondria were evaluated. The energy-coupling processes, active K+ transport and oxidative phosphorylation, were affected most by di-n-butyl phthalate and mono(2-ethylhexyl) phthalate. Mono-...

Prevention of di (2-ethylhexyl) Phthalate-induced Testicular Disturbance in Mice by Co-administration of L-carnitine